It is thought that this substance may have a number of health benefits including: Lowering the risk of metabolic syndrome, which is a risk factor for a number of conditions including increased belly fat, high blood pressure, and high blood sugar Lowering high cholesterol 1 Insulin Resistance Inositol is an insulin sensitizer. Inositol, in particular, Myo-inositol is effective as well as part of the treatment for mood and anxiety problems, as well as Managing PCOS or Polycystic Ovary Syndrome in women. It affects the insulin response and a range of hormones related to mood and cognition. Supports Regular Menstruation and Healthy Ovulation. Carnitine, an amino acid found in meat, may also lead to weight loss. You can also take higher doses from 5-15 grams a day. Women with PCOS have low levels of DCI, due to a poor conversion enacted by the enzyme epimerase, which is more evident in obese women or women with familiar diabetes. Studies show that inositol may improve the function of the ovaries and fertility in women with PCOS. There are reasons for taking a larger dose and its benefits which I will cover below. PCOS is a very common metabolic, hormone and reproductive disorder that affects anywhere from 10% to 21% of women in some parts of the world. Summary Inositol may help reduce blood triglyceride levels,. Summary Inositol is a promising compound to improve several aspects of reproductive function in women with PCOS, including menstrual cycle regularity, ovulation and fertility. Inositol is known as a second messenger, which means it helps relay messages from hormones like insulin or even follicle stimulating hormone (FSH) from the outside to the inside of your cells. In a year-long study, 80 women with metabolic syndrome were given 2 g of Inositol twice daily. This leads to a number of inositol benefits, with the first coming as no surprise: 1. Inositol supplements have been found to have numerous health benefits for women with PCOS. 3. At the end of six months, the women taking inositol had significantly reduced blood pressure, insulin resistance and cholesterol. Supplemental inositol is used in the treatment of a number of physical conditions and disorders, including psoriasis, high cholesterol, hair loss, and diabetic nerve pain, as well as a range of cognition and mood-related conditions. A 12-week study on women with PCOS found that inositol supported many metabolic health changes, including positive changes in weight loss and HDL (good) cholesterol and reduced LDL (bad cholesterol) and triglycerides. Inositol can act as a 'secondary messenger', especially for women, who consume high levels of carbohydrates. . At the end of the year, they all showed improvement in their metabolic syndrome. Tell us! A 2016 study put myo-inositol and metformin head-to-head, and found that the effects on menstrual cycle regularity were the same for these two treatments. . Essentially, inositol makes your cells more responsive to hormones or signals, which can positively impact the hormonal messages needed for fertility. If you really want to take it before sleep you can - it won't cause any issues with your sleep. As for how how much you should take I personally recommend taking anywhere from 400-2000mg a day. A 2020 review found many studies demonstrating the effectiveness of inositol as a treatment for people with PCOS. Most of the women showed reduced blood triglyceride and total . 8) Inositol lowers testosterone levels The male hormone isn't just for men. Inositol might balance certain chemicals in the body to help with mental conditions such as panic disorder, depression, and obsessive-compulsive disorder. 13-22,32 32 Clinical doses of myo-inositol may be best achieved in supplemental powdered form. Metabolic syndrome is similar to polycystic ovary syndrome in many respects. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement. Research has shown that women benefit from inositol supplementation for health conditions as mild as PMS or as severe as PCOS, as well as the conditions mentioned in the benefits section. Treatment with inositols has been shown to help improve insulin sensitivity and reduce male hormone levels in females with PCOS. It's also present in women, but those with PCOS have higher testosterone levels than normal. Now a new study (4) suggests inositol may help with metabolic health in postmenopausal women. Objective: The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women. When we are generally feeling better, we find it easier to control emotional overeating and stay away from junk food - which eventually results in healthy weight loss. This can lead to masculine features in PCOS women, such as female pattern baldness, excessive hair growth in non-feminine body parts, acne, and the loss of regular menses. These biomechanisms spell out the metabolic and cognitive benefits of inositol, which amount to direct and indirect improvements in brain health, energy, sexual health, and skin health. Inositol, also called Myo-inositol, is a carbohydrate compound that is produced naturally in the body and is also found in many plant foods like fruit and nuts. In one of these studies, a myo-inositol and D-chiro-inositol combination therapy was found to improve oocyte quality, embryo quality, and pregnancy . It is made naturally in the human body from glucose. Choline Benefits Choline is an essential nutrient that, like inositol, is present in some foods and available as a dietary supplement, according to the National Institutes of Health (NIH). Choline and inositol are often combined in supplement form. However, if you are interested in using products, many naturalistas are partial to the vitamins, leave-ins, and hair oils. While no supplement can be considered 100% safe, all our research to date shows that inositol is generally very safe, even during pregnancy. 4. Through increasing serotonin levels, inositol lifts mood and even helps with mental health issues, such as depression, OCD and anxiety ( 4 ), ( 5 ), ( 6 ). Researchers have linked this to having too little MI and too much DCI in the ovaries. Promotes Healthy Female Fertility. As with depression, the effects of inositol on bulimia seem to be more evident in women than in men. Doses for these. Inositol plays an important part in cell growth and functioning. The same effects can be used in pregnant women to stimulate the muscular contractions in pregnancy to induce labor. . In short, the science behind myo-inositol, ovulation, and people with PCOS and insulin resistance is promising: Myo-inositol may help regulate ovulation and reproductive hormone levels. (4) Does Inositol Increase Testosterone? Inositol is a type of sugar molecule, similar to glucose, but with several substantially different biological functions. Inositol is produced by the body and is found naturally in foods. Ovulation: People with PCOS might not ovulate every month or at all. Published studies confirm that inositol supplementation can improve insulin sensitivity, reduce serum levels of insulin, testosterone, and LH, and induce ovulation in women with PCOS. Myo-inositol is a specific form of inositol. Inositol, also known as myo-inositol, or cyclohexanol, is a water-soluble vitamin B complex that can be naturally found in foods like cantaloupe, most citrus fruits, corn, rice and beans. Some of these studies are using myo-inositol, others d-chiro and still . It has been studied extensively for use as a dietary supplement due to its many potential health benefits for women with PCOS. Health Benefits of Myo and DCI Inositol Regulates menstrual cycles Promotes Ovulation Improves egg quality Curbs carb cravings Decreases the risk of gestational diabetes in pregnancy Lowers insulin and glucose Lowers cholesterol Lowers inflammation Improves anxiety Improves acne Myo and d-Chiro Inositol Combined It can lower free insulin levels in women with PCOS. 5. When I first learned about these amazing inositol health benefits, I wanted to get started right away. It thus helps to sensitize cells to serotonin's mood-boosting signals. Web portal of investigation on the benefits of D-Chiro-Inositol for those who want a deeper insight on this substance and its benefits in treating dysfunctions like PCOS . Neural Support - in addition to facilitating cell membrane formation, inositol may also aid with the process of neurogenesis, or the creation of neurons. In one study, 4 grams of inositol and 400 mcg of folic acid taken daily for 3 months induced ovulation in 62% of treated women ( 20 ). Evidenced benefits included: improving ovarian function and fertility decreasing. Unlike many nutrients that target key neurotransmitters and hormones when promoting sleep, inositol plays the role of a secondary messenger (known as inositol phosphates) in various signal transduction pathways of neurons, which are utilized by sleep-promoting hormones such as serotonin. It can ease constipation-by stimulating muscular action in the intestines. Myo-inositol and its benefits for PCOS Several clinical studies have shown that the constant intake of myo-inositol is able to restore both ovarian and metabolic function [3] [4]. :: Inositol Benefits & Functions: 1. important in fat and cholesterol metabolism: 2. . Polycystic ovary syndrome (PCOS) is a condition that affects a woman's hormone levels.Women with PCOS produce higher-than-normal amounts of male hormones. What benefits have you seen by taking inositol? It has also been shown to be helpful in gestational diabetes, and in raising adiponectin, necessary for weight loss. Well, she added a few things. . Inositol is good for hormone-balancing in women in general, even outside of PCOS. Methods: Forty women aged 45-55 years and at least 6 months of amenorrhea were enrolled in this study. To Sum Up In one study, women who were postmenopausal and had metabolic syndrome took inositol supplements for one year. Neurological usage of inositol tends to require higher doses, and while antidepressant effects have been noted as low as 6g at times the standard dose is between 14-18g daily. Current research suggests that for women with PCOS, 2000mg myo-inositol taken 1-2 times daily for 3 months is an effective protocol to begin with before reviewing the programme. Your body can also produce inositol from the carbohydrates you eat. The disorder is characterized as a constellation of symptoms that can impact multiple aspects of a woman's life and health, including metabolic, reproductive and mental and psychosocial health. Anxiety Disorder and Depression Studies have shown that women with PCOS who take an inositol supplement each day will reduce their insulin resistance, improve their hormone levels, and have more regular menstrual cycles. Sources: Facchinetti F. 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