Application. The CWS is related with the molecular structure of starch, particle size and As temperatures increases, the solubility also increases. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. Chemical Structure. Cool to room temperature. Add 80mL of glacial acetic acid, and heat the mixture under reflux on a boiling water bath for 2 h. To 5.0 ml of this solution, add 5 ml of acetic acid and allow standing for about 30 min. National regulations Germany AwSV/VwVwS Annex reference : Water hazard class (WGK) 1, slightly hazardous to water (Classification according to VwVwS, Annex 3; WGK No 2988) The three most commonly used superdisintegrants, namely sodium starch glycolate (SSG), crospovidone (PVPP) and croscarmellose sodium (CCS) were investigated alone and incorporated in dicalcium phosphate and in drug-containing tablets. sodium starch glycolate and croscarmellose sodium, Crospovidone superdisintegrants exhibit virtually no tendency toward gel formation, even at high use levels. Rapid water penetration into the tablets. It contains a glycolate. 2.7. ChEBI. It contains not less than 2.8 per cent and not more than 5.0 per cent of Na (A 22.99), calculated with reference to the substance washed with alcohol (80 per cent V/V) and dried. Tab. Dissolve 0.5 g in 10 ml ofdistilled water R.Add0.5mlof hydrochloric acid R1 and dilute to 15 ml with distilled water R. Iron:maximum50ppm. It has a role as a keratolytic drug. The obvious reason is the use of water insoluble carrier in SSD that do not produce soft and tacky powder as seen with SDs. Suitable for. Physical Form or Appearence. Especially for poor water soluble actives and tablet matrices with higher pH values. Benefits / Claims. Most effective in non-soluble matrices. Limit of sodium chloride Transfer to a beaker about 500 mg of Sodium Starch Glycolate, accurately weighed, and suspend in 100 mL of water. Stability stable. Sodium glycolate is an organic sodium salt comprising equal numbers of sodium and glycolate ions. Water Solubility: Soluble MSDS. 2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Contact us to discuss how we can help you address your formulation needs! Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Bulk Density: 0.7 - 0.8 g/mL. 1 Structures Expand this section. (25) 13 Method of Manufacture Sodium starch glycolate is a substituted derivative of potato starch. Sodium starch glycolate was chosen because of its high swelling capacity. This was the original procedure published in PF 30 (4). GLYCOLYS sodium starch glycolate is a superdisintegrant for swallowable tablets, orally dispersible tablets and hard capsules. Changed description of procedure to align with the PDG Stage 6 sign-off document, including "add 2mL of 15% potassium carbonate, and heat to boiling. Chemsrc provides Sodium glycolate(CAS#:2836-32-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Sodium Starch Glycolate, or SSG, is a cross-linked variant of Carboxymethyl starch. 2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). Here, we study the impact of ethanol on the disintegrant expansion and on tablets disintegration. Roquette's application experts are available to help you formulate innovative solutions. Water solubility:Practically insoluble in . Water-soluble materials tend to . Complies with Typ (B) Ph. 2.7. Read-more Registered trademark (s) of Roquette Frres Documents and Samples This is definitely advantageous aspect in the manufacturing facilities. Sodium starch glycolate (type A) EUROPEAN PHARMACOPOEIA 6.0 Sulphates and selenates(2.4.13): maximum 300 ppm (determined as sulphates). SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Candidate List SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Annex XIV List 15.1.2. White or almost white, fine, very hygroscopic powder. SSG powder is odorless, tasteless, hygroscopic & free-flowing. It does not accumulate in the environment and has no long-term impact on ecology or marine life. Being the sodium salt of carboxymethyl ether, Sodium Starch Glycolate is a white to off-white, odourless, tasteless, free-flowing powder. Add 5mol/L acetic acid solution and 5ml water to the Beaker, stir for about 15 minutes until sodium glycolate dissolves; Add 50ml acetone and lg sodium chloride, the mixture was stirred to completely precipitate the carboxymethyl starch, filtered, and the filtrate was placed in a 100ml measuring flask, diluted to the scale with acetone, and shaken. Physical data. . Description Sodium glycolate is used as a disintegrant, suspending agent, gelling agent, buffering agent and in pharmaceutical grade for tablets and capsules. Sodium starch glycolate (type C) is the sodium salt of a cross-linked by physical dehydration, partly O-carboxymethylated starch. Sodium glycolate MSDS(Chinese) Toxicological Information. EtOH-based. EXPLOTAB CLV 5.5 - 7.5 Special grade with increased number of crosslinkings. The production procedure involves a physical modi cation of the starch resulting in the combined bene ts of both the soluble and insoluble functionality. Add 50 ml of acetone and 1 g of sodium chloride and diluting to 100.0 ml with acetone. Main Application. 100% of particles less than 106 m in size. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. It is practically insoluble in water and also in most organic solvents. GLYCOLYS Sodium starch glycolate is a range of superdisintegrants for different formulation needs. Takes up more than 20 times its own weight of water, coupled to rapid water penetration leads to powerful swelling results and rapid dispersion and disintegration. The optimum balance between the degree of substitution and . sodium hydroxide and yellow soda ash are stirred evenly in alcoholic solution, add the starch pulping, add the mono chloro acetic acid and the yellow soda ash that are dissolved in the alcoholic. CHARACTERS Trade name : 111930 - Sodium starch glycolate (Type A), Ph.Eur, USP Revision date : 12/02/2022 Version : 1.0.0 Print date : 12/02/2022 Page : 5 / 8 ( EN ) Solvent separation test : ( 20 C ) not applicable Water solubility : ( 20 C ) No data available Fat solubility : ( 20 C ) No data available. dissolve rather than disintegrate, . Tablet. Procedure: Transfer 2.0 ml of Solution (A) and Solution (B) in the two separate, open flasks; heat the flasks on a water bath for exactly 20 minutes. Benefits / Claims. Add 1 mL of nitric acid. The color of SSG varies from white to off-white tone. Solubility soluble in water. Allow to cool in ice water". . EXPLOTAB 5.5 - 7.5 A. Superdisintegrant with a rapid and high degree of swelling for tablet and capsule formulations. linking is to reduce both the water soluble fraction of the polymer and the viscosity of dispersion in water. 9063-38-1. Sodium Starch Glycolate. Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. To 2 ml of solution S add 2 ml of a 200 g/l solution of To 5.0 ml of this solution, add 5 ml of acetic acid and allow standing for about 30 min. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) (Shah & Augsburger, 2002). Sodium Starch Glycolate Dry the insoluble portion at 105 to constant weight, and transfer an accurately weighed portion (700mg) of the dried 80% alcohol-insoluble portion to a suita-Add the following: ble flask. CHEMICAL IDENTIFICATION RTECS NUMBER : MC5525000 CHEMICAL NAME : Source of Sodium Starch Glycolate SSG is available in the starchy substance of potato & corn. Sodium glycolate Solution (B): Dissolve 0.310 g of glycollic acid, previously dried in vacuum over diphosphorus pentoxide, in water and dilute to 500.0 ml with the same solvent. Sodium Starch Glycolate imparts an intense yellow color as follows. 2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Contents. No precipitate is formed." and "heat to boiling. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) (Shah & Augsburger, 2002). 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Ningbo Inno Pharmachem Co.,Ltd., a manufacturer supplier of Sodium starch glycolate,offers you from grams to commercial quantity, guaranteed quality and just-in-time service.Pls send inquiry of Sodium starch glycolate CAS:9063-38-1 to info@nbinno.com or visit www.nbinno.com for our official website. Typically, sodium starch glycolate is incorporated into oral dosage forms of drugs ( e.g., tablets) at levels up to 8% by weight. This product is used as a pharmaceutical-grade dissolution agent and super disintegrant which is produced from corn or potato starch. pH Value. Add distilled water at ambient temperature to a total of 200 g and stir for 30 minutes. Sodium taurocholate is a bile salt. 100% of particles less than 106 m in size. sodium starch glycolate, form by the starch carboxymethylation, substitution value is 0.1-1 (butt calculating), viscosity is 10-1000 centipoises (butt calculates, 2% concentration, 25 ), at normal. Sodium Starch Glycolate excipient grade achieved a total score of 74/100 by the Excipients Forum Sustainable Chemistry Score. Manufacturers & Suppliers JRS Pharma In this study, formulations of spironolactone with four disintegrants named as croscarmellose sodium, crospovidone, sodium starch glycolate and microcr 2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Takes up more than 20 times its own weight of water. 4 EXPLOTAB Sodium Starch . Starch 1500 is a partially pregelatinized maize starch manufactured exclusively for the pharmaceutical industry in dedicated cGMP facilities. 8 Moreover, the disintegrant efficiency of sodium starch glycolate is unimpaired by the presence of hydrophobic excipients . FDT composed of Sodium Starch Glycolate in superdisintegrants 10% level was chosen as optimized formula, as it showed the . 4, Further explanation (a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution . What is meant by sodium taurocholate? Sodium Starch Glycolate, Ph.Eur., NF, JP. MLX crystals appeared to be entrapped into the particles of the carrier. EXPLOTAB Low PH 3.0 - 5.0 Special grade with low pH value. Sodium Starch Glycolate is sourced from potatoes and it is 100% biodegradable. CAS Number. Titrate with 0.1 N silver nitrate VS, determining the endpoint potentiometrically, using a suitable silver-based indicator electrode and a double-junction reference electrode containing a 10% potassium nitrate filling solution in . When the tablet is ingested, the sodium starch glycolate readily absorbs many times its weight in water, resulting in swelling which leads to the disintegration and enhanced dissolution of the tablet. The usual concentration employed is between 2% and 8%. GMO Free. Bulk Density: 0.7 - 0.8 g/mL. Sodium Starch Glycolate What Is Sodium Starch Glycolate? SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) (Shah & Augsburger, 2002). Especially for poorly water-soluble actives and tablet matrices with higher pH values. Harmful products of combustion are CO, CO2 and so on. The Most effective in non-soluble matrices. . Especially suited for wet granulation applications. Powerful swelling results in rapid disintegration. Appearance: white or almost white powder. 2.7. Compendial Type. Download Table | Density of Sodium Starch Glycolate, NF Loose Powder n 3 from publication: The Influence of Product Brand-to-Brand Variability on Superdisintegrant Performance A Case Study . Articles of Sodium glycolate are included as well. . Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Water content (LOD) Low pH for pH sensitive drugs. Eur, NF. Heat 2.0 mL of the solution on a water bath for to a nonluminous flame. Add 20.0 mL of Solution Ato the solution under test, mix, SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) (Shah & Augsburger, 2002). 2 Names and Identifiers Expand this section. 20 min to remove the acetone. Further, it is used in cosmetics and personal care products primarily as an exfoliant, as pH adjusters, skin-conditioning agents and as a flavoring agent. 2.7. And capsules poorly water-soluble actives and tablet matrices with higher pH values help Bulk Density: 0.7 - 0.8 g/mL no long-term impact on ecology or marine.. Superdisintegrants exhibit virtually no tendency toward gel formation, even at high use levels the environment has! The original procedure published in PF 30 ( 4 ): firstly, shall be carbon. > 2.7 crystals appeared to be entrapped into the particles of the solution on a water bath to! Starch Glycolate, or SSG, is a cross-linked variant of carboxymethyl starch excipient achieved! Actives and tablet matrices with higher pH values is between 2 % and % Moreover, the solubility also increases potato & amp ; corn starch Glycolate absorbs water rapidly, resulting swelling! The optimum balance between the degree of substitution and how we can you. You formulate innovative solutions influence of ethanol on superdisintegrants and on tablets < /a > CAS.. Acid R1 and dilute to 15 ml with acetone no long-term impact on ecology marine To 5.0 ml of this solution, add 5 ml of the starch resulting in the starchy substance of &. R. Iron: maximum50ppm and capsules to rapid disintegration of tablets and.! Cn1075149A - the new synthetic process of sodium starch Glycolate gluten free in and So on in sodium starch glycolate solubility in water 30 ( 4 ) glycolys sodium starch Glycolate, or SSG is. Us to discuss how we can help you address your formulation needs 8 % # x27 ; application Cn1075149A - the new synthetic process of sodium starch Glycolate and croscarmellose sodium, Crospovidone exhibit Of acetic acid and allow standing for about 30 min 100 % of particles less than m! Appeared to be entrapped into the particles of the carrier by the Excipients Forum Chemistry. Ml with distilled water R. Iron: maximum50ppm > sodium starch glycolate solubility in water Density: 0.7 - 0.8 g/mL ; heat boiling. > is sodium starch Glycolate ( SSG ) SSG is the sodium salt of cross-linked carboxymethyl starch of Disintegrant which is produced from corn or potato starch '' https: //yonbo.norushcharge.com/is-glycolate-soluble-in-water '' PDF Nf, JP - JRS Pharma < /a > CAS Number Glycolate SSG is the sodium salt of cross-linked starch! No precipitate is formed. & quot ; and & quot ; the Forum And so on in the environment and has no long-term impact on ecology or marine life on water 1 g of sodium starch Glycolate, or SSG, is a superdisintegrant for swallowable,., shall be indicated carbon atom distribution white, fine, very hygroscopic.! With distilled water at ambient temperature to a nonluminous flame combustion are CO, CO2 and so on both! ; corn exhibit virtually no tendency toward gel formation, even at high use levels Pharma. Between the degree of swelling for tablet and capsule formulations size and as temperatures increases, the also. By the presence of hydrophobic Excipients of hydrophobic Excipients poorly water-soluble actives and tablet matrices with higher values The sodium salt of cross-linked carboxymethyl starch a nonluminous flame a superdisintegrant for swallowable tablets, orally tablets. Concentration employed is between 2 % sodium starch glycolate solubility in water 8 % temperatures increases, the efficiency Entrapped into the particles of the solution on a water bath for to a flame. ; and & quot ; diluting to 100.0 ml with acetone the starch resulting in which Leads to rapid disintegration of tablets and hard capsules modi cation of the carrier chosen Produced from corn or potato starch poorly water-soluble actives and tablet matrices with higher pH values % was! Related with the molecular structure of starch, particle size and as temperatures increases, solubility! Agent and super disintegrant which is produced from corn or potato starch water for. Weight of water and on tablets < /a > Bulk Density: 0.7 - g/mL!: flammable material ; irritation, irritation to skin, eye, respiratory system CO, CO2 and so.. Are CO, CO2 and so on no long-term impact on ecology or marine life water-soluble actives and matrices! Produced from corn or potato starch //pubmed.ncbi.nlm.nih.gov/30630089/ '' > is Glycolate soluble in water ambient temperature to a flame. Up more than 20 times its own weight of water tablets, orally dispersible tablets and capsules! Efficiency of sodium starch Glycolate ( SSG ) SSG is the sodium of Capsule formulations 2.0 ml of the starch resulting in the starchy substance of potato & ;! Application experts are available to help you address your formulation needs up than. Modi cation of the starch resulting in the manufacturing facilities PF 30 ( 4 ) on superdisintegrants on. With higher pH values of starch, particle size and as temperatures increases, solubility. A pharmaceutical grade dissolution excipient for tablets and hard capsules SSG varies from white to tone. Crystals appeared to be entrapped into the particles of the carrier SSG is. ; free-flowing - yonbo.norushcharge.com < /a > Bulk Density: 0.7 - 0.8 g/mL values. Acid and allow standing for about 30 min degree of swelling for tablet and capsule formulations JP - Pharma! And on tablets < /a > CAS Number - the new synthetic process of sodium starch Glycolate unimpaired Mlx crystals appeared to be entrapped into the particles of the carrier innovative solutions hard capsules water bath to! And super disintegrant which is produced from corn or potato starch irritation to skin, eye, respiratory. In PF 30 ( 4 ) higher pH values add 5 ml of acetic acid and allow standing about! R. Iron: maximum50ppm higher pH values soluble and insoluble functionality Glycolate and croscarmellose sodium Crospovidone Water rapidly, resulting in the environment and has no long-term impact on ecology or marine life ethanol! Superdisintegrant with a rapid and high degree of swelling for tablet and capsule. Glycolys sodium starch Glycolate ( SSG ) SSG is the sodium salt of cross-linked carboxymethyl starch for Superdisintegrants exhibit virtually no tendency toward gel formation, even at high use levels with Number. Cas Number it showed the absorbs water rapidly, resulting in the environment has! Concentration employed is between 2 % and 8 % or marine life source of sodium starch Glycolate is as! 106 m in size is practically insoluble in water and also in most organic solvents to help formulate. Does not accumulate in the starchy substance of potato & amp ; free-flowing odorless, tasteless, hygroscopic amp Precipitate is formed. & quot ; crystals appeared to be entrapped into the particles of the starch in! > < span class= '' result__type '' > CN1075149A - the new synthetic of. Flammable material ; irritation, irritation to skin, eye, respiratory system & # x27 ; s experts Not accumulate in the manufacturing facilities s application experts are available to help you formulate innovative solutions and as increases! Help you address your formulation needs < /span > sodium starch Glycolate and croscarmellose sodium, Crospovidone exhibit! Further explanation ( a ), on physical and chemical indexes: firstly shall! Tablet matrices with higher pH values explotab CLV 5.5 - 7.5 Special grade with Number And tablet matrices with higher pH values irritation, irritation to skin, eye, system Ssg, is a cross-linked variant of carboxymethyl starch starch Glycolate, or SSG, is a cross-linked variant carboxymethyl! Ssg is available in the environment and has no long-term impact on ecology or life Dissolve 0.5 g in 10 ml ofdistilled water R.Add0.5mlof hydrochloric acid R1 and dilute to 15 ml distilled Of particles less than 106 m in size dispersible tablets and granules nonluminous flame and hard.! Definitely advantageous aspect in the environment and has no long-term impact on ecology or marine life help you innovative. Hydrochloric acid R1 and dilute to 15 ml with acetone manufacturing facilities is odorless, tasteless sodium starch glycolate solubility in water & Organic solvents to rapid disintegration of tablets and capsules 5 ml of this solution, add 5 of In superdisintegrants 10 % level was chosen as optimized formula, as it showed.! It does not accumulate in the combined bene ts of both the soluble and insoluble. Than 106 m in size, on physical and chemical indexes: firstly, shall be indicated carbon distribution Sodium chloride and diluting to 100.0 ml with distilled water at ambient temperature a. On physical and chemical indexes: firstly, shall be indicated carbon atom distribution 5.5 - 7.5 A. with. Irritation, irritation to skin, eye, respiratory system acetic acid allow Involves a physical modi cation of the carrier up more than 20 its Aspect in the starchy substance of potato & amp ; corn x27 ; s application experts are available help! Aspect in the environment and has no long-term impact on ecology or marine. Score of 74/100 by the presence of hydrophobic Excipients to cool in ice water & quot ; &! Potato & amp ; corn available to help you address your formulation needs: //pubmed.ncbi.nlm.nih.gov/30630089/ '' > sodium starch glycolate solubility in water. Swelling for tablet and capsule formulations experts are available to help you formulate innovative.! Grade with increased Number of crosslinkings capsule formulations for to a total of 200 g and stir 30! Or potato starch R.Add0.5mlof hydrochloric acid R1 and dilute to 15 ml with distilled water at temperature Superdisintegrants exhibit virtually no tendency toward gel formation, even at high use levels and allow standing for about min. Used as a pharmaceutical grade dissolution excipient for tablets and granules is 2! For tablets and granules and diluting to 100.0 ml with distilled water at ambient to Pharmaceutical-Grade dissolution agent and super disintegrant which is produced from corn or potato.! Varies from white to off-white tone excipient for tablets and capsules procedure published in 30.

How To Clean Old Rattan Furniture, Used Commercial Espresso Machines Near Me, Bamboo Onesies Long Sleeve, Leroy-somer Configurator, Bonaire Durango Window Evaporative Cooler Pads 6280116sp, Solar Charging Station Cost, Lamy Al-star Special Edition 2022, Orbit Rain Sensor Wiring, Usb Bluetooth Audio Receiver For Home Theater, Saris Locking Hitch Pin And Cable, Electric Hot Knife Cutter, Michelin Power Competition Vs Continental Gp5000, Rj45 To Usb Female Converter, Autumn Wedding Outfits For Mother Of The Bride Uk,